Purpose/Significance The paper introduces the innovative practices of the all-scenario intelligent logistics management of the intelligent twins of the Guangdong Second Provincial General Hospital, and provides experiences for intelligent hospital logistics management.Method/Process With the internet of things (IoT), cloud computing, and artificial intelligence (AI) as the core technologies, an integrated hospital intelligent system with three-dimensional perception, global collaboration, accurate judgment, and continuous evolution is built, and a standardized, streamlined, and refined management mode for logistics management for human, goods, and security services is explored. Result/Conclusion The all-scenario intelligent logistics management mode based on the hospital intelligent twins technology realizes the closed-loop management for the whole process of identification of personnel entering and exiting the hospital, exerts its advantages in the management of facilities and equipment scheduling, the recycling and disposal of medical waste, and improves the safe operation efficiency of hospital equipment, management efficiency of sanitation and cleaning, and work efficiency of safety protection.