Purpose/Significance Based on the current situation of practice teaching of medical information engineering specialty, the paper puts forward reform countermeasures and suggestions to improve the level of teaching of medical information engineering specialty and provide references for the research of practice teaching of medical information engineering specialty. Method/Process The paper analyzes the characteristics and development status of medical information engineering specialty under the background of new engineering discipline construction, and designs feasible reform plans from various aspects such as professional practice teaching mode and so on. Result/Conclusion The construction of the practical teaching mode with project teaching as the carrier and the improvement of professional knowledge, ability and quality as the core can stimulate the enthusiasm of teachers and students, which is conducive to the improvement of professional teaching effect.