Purpose/Significance The study deeply integrates information education into the cultivation of medical talents, improves the quality of medical talents cultivation, and explores new directions for higher medical education reform. Method/Process Combining with the practical experiences of the integration of informatics in medicine in Shanxi Medical University, the paper expounds the construction path of integration of informatics in medicine talents training system.Result/Conclusion It forms the transformation mode from knowledge production to students’ cognitive construction, improves the constructivism education and teaching theory, and has significant theoretical guiding significance for the training of medical talents in the process of interdisciplinary integration.