Purpose/Significance To improve the graded protection of health and medical science data, to promote data security sharing and full utilization, and to enhance the value of data resources. Method/Process The literature review method is adopted in this study, followed by multiple rounds of thematic expert group discussions to discuss the principles, rules and implementation steps of health and medical science data grading. Result/Conclusion Based on the requirements of laws, regulations, or policies related to health and medical science data, this study constructs a guideline for data classification of health and medical science data. It proposes specific principles, rating rules, and implementation steps for health and medical science data grading, providing references for data classification in the production, management and application of health and medical science data.