Purpose/Significance Based on the national strategic deployment of medical integration in the Yangtze River Delta region and the requirements of the coordinated development of the Yangtze River Delta demonstration area,the paper designs the construction architecture of the internet hospital in the area of the Yangtze River Delta which can actively integrate high-quality medical resources to ensure resource supply, and rapidly improve the level and quality of regional medical services.Method/Process By means of the design of internet medical service platform, the telemedicine collaborative platform and the data interconnection platform, reasonable planning and integration of existing medical information resources are carried out.Result/Conclusion The smart internet hospital of Yangtze River Delta (Shanghai) is built according to the scheme, which has achieved good operating results.