Purpose/Significance Through the design and construction of the information system, it is intended to meet the overall needs of continuous health monitoring and disease prediction for the elderly at home.Method/Process 5G, Wi-Fi network technology as a communication link, combined with artificial intelligence (AI) technology to design home-based elderly care health management system. The paper analyzes the current products situation of the same type, expounds the logical hierarchy structure of the system, the main development technology, and focuses on the relevant functional modules and the technical realization methods. Result/Conclusion The system basically realizes the functional requirements of real-time health monitoring, vital signs data collection, and AI disease prediction for the elderly at home. It has certain reference value for the health management of the elderly at home to alleviate the aging population.