Purpose/Significance The data acquisition system is designed to solve the problem of heavy workload in collecting electronic health record (EHR) data, electronic medical record (EMR) data and whole population data for Shenzhen National Health Information Platform, and to improve the level of public health informatization in Shenzhen. Method/Process Through the deployment of data acquisition software in the front server of various medical and health institutions in Shenzhen, the relevant original data is converted into standard format and loaded into the front database through integrated services such as data collection, cleaning and uploading in accordance with the relevant specifications of data collection. Result/Conclusion Three basic databases are established by using the data acquisition system, so that the medical and health information of the city residents could be preserved completely.