Purpose/Significance To explore the optimization scheme of clinical pathway information management tools based on hospital information system (HIS), so as to improve clinical pathway management level. Method/Process In combination with the actual situation of the hospital, specific methods are proposed to optimize the clinical path system, such as clarifying the system interface, increasing the path medical order replication and medical order status check, optimizing the branch path design, and reducing the false positive variation of drug medical order. Result/Conclusion The clinical pathway system is effectively optimized, the work efficiency and implementation effect of clinical pathway are improved, and references are provided for the continuous improvement of clinical pathway management.