Purpose/Significance To optimize the innovation and entrepreneurship education practice system based on the “internet+medical” competition of the College of Computer and Information of Inner Mongolia Medical University, to help the school construct new medical science and achieve a new situation of higher quality entrepreneurship and employment, so as to provide references for other universities or colleges with similar disciplines. Method/Process With the innovation and entrepreneurship competition as the starting point, ideological and political education will be runned through the whole process, the practice system of innovation and entrepreneurship education by integrating the advantageous resources of schools and enterprises will be optimized, and the teaching reform of innovation and entrepreneurship education will be deepened. Result/Conclusion The scale of innovation and entrepreneurship competition has increased significantly, the integration and innovation of disciplines has been further highlighted, and the quality of projects has been further improved.