Purpose/Significance To establish the clinical application evaluation and management system of artificial intelligence (AI) medical technology in China, and to support clinical rational use decision-making. Method/Process Literature analysis, expert consultation and empirical research methods are used to summarize practical application experience and form a guide text for clinical application evaluation of AI medical technology. Result/Conclusion The paper studies and explores the definition and classification of AI medical technology, topic selection, evaluation method selection, index system construction, quality control requirements, and forms a guideline for clinical application evaluation of AI medical technology in China. Through empirical research, the evaluation guideline helps to support clinical rational use decision-making, and lays a solid foundation for the standard development of clinical application evaluation of AI medical technology.