Purpose/Significance To replace the traditional manual reporting mode, to improve the rate of single-disease data filling automatically, to connect directly with the National Single-disease Quality Management and Control Platform to report the data, and to provide statistical analysis data to the hospital management departments for standardizing diagnosis and treatment behaviors as well as improving medical service level. Method/Process The single-disease management system is built, and a knowledge base for automatic extraction of single-disease data is established. Natural language processing technology is used to realize the automatic extraction of single-disease data, and the front-end technology is used to realize the connection with the National Single-disease Quality Management and Control Platform.Result/Conclusion The single-disease management system solves the problems of low reporting efficiency, untimely reporting and incapability of quality control, improves the reporting efficiency of single-disease data, ensures the reporting rate of single-disease reach 100%, and improves the medical quality of the hospital.