Purpose/Significance Through the establishment of the pharmaceutical rebate prevention system, the capacity of prevention of pharmaceutical rebate can be improved, and the data security of patients can be protected more effectively.Method/Process With the help of information security equipments such as network access control, database audit, and resource monitoring platform, the algorithm of the original pharmaceutical rebate prevention system is optimized, and the comprehensive mobile terminal platform is combined to achieve a full range of pharmaceutical rebate prevention system and online audit and archiving.Result/Conclusion A more comprehensive defense system is built, and the system provides a more timely and efficient prevention and control means with clearer positioning for data security management departments and discipline inspection departments.