Purpose/Significance Combined with flipped classroom and project-driven teaching mode, the curriculum reform is explored to improve teaching effect, stimulate students to learn independently and participate deeply in class. Method/Process Taking the teaching of hospital information system course as an example, guided by the flipped classroom concept and combined with the project-driven method, the paper puts forward the reform plan of teaching design and applies it to the actual teaching process.Result/Conclusion The satisfaction degree of the students is higher, the initiative of students to study independently is improved, and the teaching quality is enhanced.