Purpose/Significance By using data mining methods, the medication rules and prescription characteristics of traditional Chinese medicine (TCM) for treating hypertension with preserved ejection fraction heart failure are discussed. Method/Process The database is established based on the TCM prescription information of hypertensive patients with preserved ejection fraction heart failure admitted to the Cardiovascular Disease Department of the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from January 2019 to July 2022. SPSS Statistics and Moderler software are used to analyze the frequency, taste, meridian tropism, efficacy, association rules, clustering and factor analysis of the prescriptions to explore medication rules.Result/Conclusion TCM in the treatment of hypertension with preserved ejection fraction heart failure is mainly to replenish qi and spleen, nourish the heart and calm the mind, relieve phlegm, relieve cough and asthma, and pay attention to promoting blood circulation and removing blood stasis, promoting water infiltration and dampness, which can reflect the overall concept of TCM and the characteristics of diagnosis and treatment based on syndrome differentiation and provide references for clinical medication.