Purpose/Significance By integrating clinical and biological sample information, a big data research platform for biological sample information resources is built to provide one-stop data retrieval, integration and analysis services for researchers, and a data governance system is established, so as to improve the level of hospital clinical research infrastructure construction.Method/Process Common data model and data governance technology are adopted to integrate data sources from different vendors through extraction, transformation, loading and other steps to provide a unified data access portal. Result/Conclusion The big data research platform for biological sample information resources has the advantages of multi-dimensional data screening and rapid integrated analysis, which can provide support for clinical research.