Significance To discuss the new demands and scenarios of disease prevention and control informatization brought about by emerging information technologies, and to provide references for the deep integration of information technology and the modernization of disease prevention and control system. Method/Process The paper analyzes the exploratory applications of emerging information technologies in electronic medical record and disease report intelligent analysis, regional syndrome monitoring, large-scale disease investigation and auxiliary epidemiological investigation, multi-channel monitoring and early warning, portable individual soldier communication under health emergency, and expounds the causes of problems that have not yet formed a systematic construction situation. Result/Conclusion Suggestions on the future development of modern disease prevention and control informatization are put forward to provide technical support for improving public health service capabilities and innovating business changes.