Significance To establish an informatization platform for nursing quality control in tertiary hospitals of Qinghai province, and to analyze its influence on nursing quality.Method/Process According to the needs of nursing quality management in Qinghai province, based on the nursing quality data platform, a nursing quality index monitoring module is established. A tertiary hospital is selected as a pilot hospital, and the nursing quality data of this hospital from January to June 2021 is selected as the control group by using the historical comparative study method, and the nursing quality data collected by the informatization platform from January to June 2022 is selected as the observation group. The changes of nursing quality before and after the application of informatization platform are compared.Result/Conclusion After the application of the informatization platform for nursing quality control, the rate of physical restraint and unplanned extubation of endotracheal intubation of hospitalized patients decreases significantly, and the score of patients’ satisfaction with nursing work increases significantly. The informatization platform has strong operability and clinical application value.