Purpose/Significance To provide new ideas for the construction of specialized disease database, clinical scientific research and hospital information interconnection in China.Method/Process Combined with the development history of domestic and foreign medical systems and medical informatization, the paper expounds the development status of specialized disease database, summarizes the two main construction modes of specialized disease database in China, puts forward the construction scheme of specialized disease database based on structured query language (SQL) integration technology and common data models. Results/Conclusion The solution can quickly build a specialized disease database and realize interconnection at the data level.