Purpose/Significance To discuss the application method and effect of the intelligent telephone follow-up system in the follow-up of patients with pulmonary nodules. Method/Process Based on the integrated care management platform, combined with the follow-up function of intelligent robots, the scripts and processes for follow-up of patients with pulmonary nodules are designed. Result/Conclusion By utilizing the intelligent telephone follow-up system, the number of successful calls per day is about 7.5 to 10.0 times that of manual calls, and the completion of follow-up is about 9.5 to 14.3 times that of the manual,which greatly improves the efficiency and effect of follow-up,and realizes high-quality services for patients.