Purpose/Significance Under the background of universal vaccination, the information system of national immunization program is reconstructed through the technical route of microservice architecture.Method/Process The domain-driven approach is adopted to design the business model and reconstruct the information system based on microservices. The process of system construction is expounded in detail, including object identification and definition, domain reorganization and aggregation, service splitting, system deployment application and effect comparison.Result/Conclusion From the functional and non-functional aspects, the overall evaluation of system data acquisition, data analysis and processing, data verification, data consumption and storage is carried out. The evaluation results show that the system function and performance are significantly improved through the transformation of microservice architecture.