Purpose/Significance The research direction and technical route of Mawangdui medical books informatization and intelligence are prospected to provide references for related research. Method/Process The paper reviews the research process of Mawangdui medical books, analyzes the problems existing in the existing studies, and probes into the possibility and technical route of three directions in the research of informatization and intelligence of Mawangdui medical books.Result/Conclusion The possibility of combining artificial intelligence technology with traditional ancient books can be studied from three directions:the construction of text corpus, the restoration of ancient medical books and knowledge extraction, so as to give full play to the value contained in Mawangdui medical books.