Purpose/Significance To analyze the development status, different modes and effects of medical alliance informatization in China, the United Kingdom(UK) and the United States(US), so as to provide references for the informatization development of medical alliance in China. Method/Process The paper uses the literature analysis method to analyze the development status of medical alliance informatization in the US and the UK, and compares and analyzes the development of medical alliance informatization at home and abroad. Result/Conclusion There are differences in the organizational structure, business operation, funding guarantee mode and historical foundation of medical alliance between China, the UK, and the US. The development of medical alliance requires the support of national policy and relevant information technology. The informatization construction of medical alliance in China should strengthen the top-level design, standard revision, standard implementation and application of medical alliance informatization.