Purpose/Significance To explore the influencing mechanism of doctor-patient communication on patient compliance.Method/Process Samples are collected randomly through the questionnaire platform, and a structural equation model (SEM) is constructed by using SmartPLS software to analyze the influence path and significance of doctor-patient communication on compliance.Result/Conclusion Doctor-patient communication has a positive impact on patient compliance through the mediating effects of patients’ trust in doctors, patients’ satisfaction with medical treatment and patients’ perceived information asymmetry.