Purpose/Significance To analyze the experimental data of Dachengqi Decoction in treating acute pancreatitis and confirm the relationship between multi-component and multi-pharmaceutical efficacy. Method/Process The paper uses orthogonal partial least squares(OPLS) regression to analyze the relationship between the Chinese medicine compatibility, the Chinese medicine components of the decoction liquid, the Chinese medicine components of the blood and the pharmaceutical efficacy indicators respectively. Result/Conclusion There are one-to-many, many-to-one, and many-to-many relationships between the Chinese medicine compatibility and the pharmaceutical efficacy indicators, the Chinese medicine components of the decoction liquid and the pharmaceutical efficacy indicators, the Chinese medicine components of the blood and the pharmaceutical efficacy indicators. The experimental results indicate that the treatment of acute pancreatitis with Dachengqi Decoction presents the characteristics of multiple components and multiple pharmaceutical efficacy.