Purpose/Significance To promote the integration and sharing of government information systems, so as to reduce the cost of government governance and modernize the governance system and capacity. Method/Process The paper takes information system integration and data sharing in Chinese Center for Disease Control and Prevention (CDC) as an example, elaborates the integration path and working result, and analyzes and discusses the difficulties and countermeasures of integration and sharing. Result/Conclusion Based on the National Health Information Construction, the general requirement is clear for unified planning and co-constructing and sharing. Exploring the big data technology to realize data fusion and application, and build a new development pattern of digital CDC.