Purpose/Significance Aiming at the problems existing in the use of clinical decision support system (CDSS), the interface design principles are put forward and applied to the construction of CDSS for arrhythmia diseases. Method/Process From the perspective of interaction design, the principles of interface design are proposed according to six dimensions:interpretability, timeliness, usability, relevance, respect and evidence-based. The assisted diagnosis and treatment of arrhythmia diseases is selected as the application scenario, and the interactive interface prototype of CDSS is designed. The design and implementation process of interface functions, information functions and interactive functions are expounded. Result/Conclusion The proposed interface design principles can effectively mitigate the existing six types of problems in CDSS and demonstrate the feasibility of applying them in a CDSS prototype for arrhythmia diseases, which has been recognized by specialists. The interaction principles are generalizable and can be used to guide the interaction design of multiple disease-assisted diagnosis and treatment tools.