Purpose/Significance To conduct a cross-metric analysis of citations and cited references of highly cited medical informatics articles in the first quartile of the journal citation reports (JCR) over the past 10 years, and to analyze the sources of citing disciplines and the origins of cited disciplines. Method/Process The screened data is divided into citation literature data and citing literature data. Statistics are performed from the perspective of secondary disciplines, and the general analysis is carried out from the perspective of first-level disciplines. The measurement indicators are set as discipline diversity, discipline balance, discipline continuity and discipline interdisciplinarity, which are analyzed respectively from the perspectives of citations and citing. Result/Conclusion The interdisciplinary characteristics of medical informatics include a wide range of disciplines involved, consistent and stable external influence, and a tendency towards certain cross-disciplinary objects, and on this basis, the suggestions for disciplinary development are proposed.