Purpose/Significance To solve the problem that regional clinical research data are difficult to integrate efficiently, and to promote “Chinese evidence” and “Chinese protocol” in the global clinical research community. Method/Process Based on the standardization theory, the data standardization system is proposed, and the construction and application methods of the regional clinical research data platform are explored with the integration of multi-center clinical research data as the starting point. Result/Conclusion The theoretical framework of the regional clinical research data platform has been preliminarily established, and the clinical research capabilities of tertiary hospitals in Shanghai have been significantly improved.