Purpose/Significance To sort out and analyze the application status of artificial intelligence (AI) large models in medicine, so as to provide new perspectives for research in this domain. Method/Process Based on a review of relevant literatures, the paper outlines the application scenarios and examples of AI large models in the fields of smart medical care, medical metaverse, medical research and development, etc. It also summarizes the risks and challenges in the application of AI large models in medicine. Result/Conclusion AI large models have great development potential in medicine, and it is necessary to promote the core technologies of AI large models and improve relevant regulations and laws.