Purpose/Significance To explore the training mode of medical engineering integration composite technical talents in the major of medical information engineering, in order to cope with the transformation of medical and health models and contribute to the Healthy China 2030 strategy. Method/Process It explores the innovative training mode for the major of medical information engineering from 3 aspects of curriculum system, faculty team, and quality assurance, emphasizes cross-disciplinary integration, builds interdisciplinary teams, and improves the monitoring system. Result/Conclusion The mode contributes to more versatile technical talents who can adapt to the needs of intelligent medicine, provides strong support for the transformation of medical and health models, and provides reference for other medical engineering integration majors.