To explore the training path of smart medical compound talents with both medical knowledge and artificial intelligence (AI) engineering technology under the background of education digital transformation. Method/Process By applying the methods of educational practice and literature research, the paper analyzes the challenges faced by education digital transformation, expounds the construction method of the “real-virtual” digital transformation model of smart medical education, and puts forward the training path of smart medical talents. Result/Conclusion Under the background of education digital transformation, it is necessary to reshape the concept of smart medical education and innovate the evaluation mode of smart medical education, realize the reform of “teaching”“learning” and “management” through the smart campus system.