The case simulation software that fits the characteristics of clinical teaching of emergency medicine is developed and applied to the clinical practice teaching of emergency medicine for medical students, so as to enrich the clinical teaching methods of emergency medicine and other specialties. Method/Process Visual Studio 2017 platform is used to develop software and realize the two core functions of editing cases and simulation exercises, and the self-designed emergency typical cases are introduced. The software is applied to the teaching practice of 50 emergency medical students, and feedback is collected through the questionnaire survey. Result/Conclusion Students recognize the novelty and overall effect of the software, and agree to use it in emergency practice teaching. The medical history collection and physical examination function areas of the software need to be improved. This case simulation software has a broad application prospect in emergency practice teaching and is worth further exploration and promotion.