To analyze the management problems of scientific data collection in the biomedical field and put forward countermeasures in order to improve the dissemination of scientific data. Method/Process Based on the relevant national scientific data collection policy, taking the National Population Health Data Center as an example, the challenges and countermeasures of scientific data collection in the biomedical field are analyzed from the perspective of scientific data manager. Result/Conclusion The paper puts forward some countermeasures to solve the problems, including popularizing the scientific data collection mechanism, setting standards and conducting audits of biomedical science data quality and standardization, strengthening data security and privacy protection technology research and development in accordance with relevant laws and regulations.