To explore the impact of participating in internet medical service on the value co-creation intention of patients with chronic diseases, and to provide suggestions for chronic disease service providers and internet medical service developers. Method/Process The patients with chronic diseases in 7 community healthcare centers in Wuhan are investigated by the questionnaire survey, and 387 valid questionnaires are collected. Structural equation model analysis is used to analyze the sample data. Result/Conclusion Innovativeness, optimism and discomfort have significant effects on the intention to use internet medical service, the intention to use internet medical service, perceived benefit and self-health efficacy have significant effects on value co-creation intention. Chronic disease service providers can improve the innovative spirit and optimistic perception of patients to improve the value co-creation intention of patients with chronic diseases.