To evaluate the applicability, feasibility and practicability of online-to-offline (O2O) mode in chronic disease management, with a view to providing the basis for the innovation and development of chronic disease management mode in China. Method/Process Relevant articles in domestic and foreign databases are searched to summarize the implementation methods of O2O mode and the application status in the management of common chronic diseases, the current problems are analyzed, and development strategies are put forward. Result/Conclusion O2O mode has been applied in fields such as disease monitoring, psychological care, health education and follow-up management, which can improve clinical symptoms and enhance patients’ self-management ability. However, O2O mode is still in the initial stage of development, and it is urgent to improve patients’ digital health literacy level, explore the construction of the best implementation platform and improve the information security system.