Purpose/Significance To reveal secondary infection knowledge related to infectious diseases by mining public literature data, and to promote the research and construction of the secondary infection monitoring platform, so as to improve the prevention and control level of infectious diseases in China. Method/Process The literature based discovery method is firstly adopted to mine and analyze the secondary diseases from large-scale biomedical literature data, taking viral hepatitis, human immunodeficiency virus(HIV)infection and tuberculosis infection as the examples. Result/Conclusion 3 kinds of secondary diseases including infectious diseases, non-infectious diseases and even tumors, are found from more than 36.8 million PubMed literature.The research results not only validate that this method provides a new approach for systematically and comprehensively reveal secondary infection knowledge related to infectious diseases, but also provide more powerful literature evidences for effective monitoring and early intervention of secondary diseases.