Purpose/Significance To analyze the multidimensional interaction between the characteristics of traditional Chinese and western medicine in patients with type 2 diabetes mellitus and its influence on traditional Chinese medicine (TCM) syndrome differentiation. Method/Process Based on the real-world electronic medical record (EMR) data, the traditional association rule algorithm is improved, and the important TCM syndromes are screened out as dependent variables by increasing the respect index, and the logistic regression algorithm is used to explore the influence of traditional Chinese and western medicine indexes on TCM syndromes. Result/Conclusion Based on 688 patients, 112 association rules are obtained, of which 12 includes TCM syndromes. The respect of association rules between middle-earth stagnation syndrome and overweight/obesity is the highest, moreover, overweight/obesity patients have a higher prevalence rate of middle-earth stagnation syndrome. There is a strong correlation between middle-earth stagnation syndrome, peripheral neuropathy or hypertension and overweight/obesity. Patients with diabetic nephropathy are more likely to have qi and yin deficiency syndrome.