Purpose/Significance The comments of internet users on paroxetine treatment of autism are mined to reveal the patients’ focus of attention and emotional attitude. Method/Process By using the biterm topic model(BTM) and sentiment analysis method, the paper analyzes the comments about paroxetine treatment of autism on multiple media platforms, and explores the topic distribution and affective tendency of the texts. Result/Conclusion The focus of attention and emotional attitude of patients to drugs are analyzed from 5 aspects, which provides valuable information for autistic patients and related medical staffs, and provides references for better meeting the needs of patients and improving their quality of life.