Purpose/Significance To analyze the problems and difficulties faced by the multi-district informatization construction of public hospitals, and to put forward the development strategy of multi-district informatization construction of public hospitals, so as to provide references for promoting the multi-district informatization construction of large public hospitals and even the sustainable development of multi-district hospitals. Method/Process The SWOT analysis is used to comprehensively analyze the development situation of public hospitals’ multi-district informatization construction. Result/Conclusion Public hospitals with multiple districts should establish a unified infrastructure base to support the homogenization of services in different districts, innovate the research and development and application of emerging technologies to realize the differentiated development of different districts, enhance the level of hospital information management and ensure the synergistic development of homogenization and differentiation.