Purpose/Significance To build a path for the cultivation of innovative practical ability, in order to solve the problems of unclear cultivation plan and imperfect effect evaluation system in the cultivation of innovative practical ability of medical information management talents.Method/Process Based on the outcomes-based education (OBE) concept and the tripartite perspective of students, colleges and universities, and employers, the paper clarifies the objectives of competence cultivation, including innovation and skill objectives. Guided by two ability objectives, integrating the CDIO engineering education model to reverse design the main line of ability cultivation,it constructs a path for ability cultivation.Result/Conclusion A complete, standardized and sustainable innovative practical ability cultivation path is finally formed to realize the cultivation of medical information management talents.