Purpose/Significance To explore new ideas of medical information curriculum group construction under the background of new medicine, and to cultivate intelligent medical talents with medical knowledge, information literacy and artificial intelligence(AI)thinking.Method/Process The paper analyzes the main problems faced by medical information courses in medical universities and colleges under the background of new medicine by means of current situation investigation and teaching practice summarization.It constructs the medical information curriculum group based on“foundational, advanced, and high-level” progressive method, reconstructs teaching content, enriches case base, and improves teaching methods in order to cultivate intelligent medical talents.Result/Conclusion The construction of the curriculum group can effectively stimulate the motivation of independent learning of medical students, and provide theoretical support and practical paradigm for the reform of medical information curriculum system in medical universities and colleges.