Purpose/Significance To construct a theoretical model for interactive evaluation of health information search systems, and to provide theoretical support for its empirical research. Method/Process Through literature review and theoretical analysis, based on the user-information/technology/task 3 dimensions interaction theory (3D interaction theory), a 3D interaction model between users and health information search systems is constructed. On this basis, a theoretical model of health information search system evaluation focused on user interaction is further constructed.Result/Conclusion The 3D interaction theory provides a theoretical analysis framework for the evaluation of health information search system. And the 3D interaction model between users and health information search system(3D-IM-U-HISS) can dynamically analyze user interaction from the aspects of demand, experience, cognition and emotion, which deepen and expand the 3D interaction theory. Based on the 3D-IM-U-HISS, the evaluation index system of health information search system is analyzed, and a theoretical model for interaction evaluation of health information search system is developed. The theoretical model is of great value for interactive function evaluation of health information search system.