Purpose/Significance To explore the influencing factors of health information acquisition behavior among chronic disease patients and provide targeted support for patient health management. Method/Process Based on the capability, opportunity, motivation-behavior (COM-B) theoretical framework, an analytical model is constructed, and 463 valid questionnaire responses are collected. An integrated approach combining structural equation modeling (SEM) and fuzzy-set qualitative comparative analysis (fsQCA) is employed to conduct empirical research. Result/Conclusion SEM analysis reveals that health literacy, information technology competence, platform accessibility, perceived ease of use, and perceived usefulness positively influences health information acquisition behavior, while the impact of infrastructure conditions is not significant. Configuration analysis (fsQCA) demonstrats that perceived usefulness is the core condition across all influencing pathways.