Purpose/Significance For the medical information management major, a multi-party collaborative double-teacher teaching mode is constructed to cultivate high-quality medical information management talents with both theoretical knowledge and practical ability. Method/Process From the perspective of multi-party collaboration, the current dilemma of double-teacher teaching in medical information management major is in-depth analyzed. Based on the theory of collaborative innovation, surrounding the core viewpoints of goal convergence, multi-subjectivity, cooperation and sharing, and innovative development, a “government-industry-university-research-medical” five-in-one double-teacher teaching mode for medical information management major is constructed, and implementation strategies of complementary development and synergistic effects inside and outside the school are porposed. Result/Conclusion The construction of double-teacher team should be strengthened, the teaching method should be innovated, the teaching content should be enriched and the teaching evaluation system should be optimized, so as to provide references for the effective construction of the double-teacher teaching mode.