Purpose/Significance By systematically sorting out the application and development of digital intelligence technology in the field of disease control and prevention, the paper demonstrates how digital intelligence technology can promote the high-quality development of disease control and prevention, and points out the development direction for the future construction of digital intelligence disease control and prevention. Method/Process The paper reviews the development process of disease prevention and control field in China from informatization to digital intelligence, details the typical applications of digital intelligence in medical prevention and coordination, infectious disease monitoring and early warning, chronic disease management, etc., and analyzes the problems of fragmentation of information resource integration, omission of the bottom of the monitoring network, and insufficient coordination and linkage of multiple parties. Result/Conclusion Digital intelligence is the key force in promoting high-quality development of disease control and prevention, and reshaping traditional disease control and prevention models. The development direction centered on “technology-led , business-driven, data-supported” is proposed.