Purpose/Significance To summarize the practical experience of the comprehensive management platform for disease prevention and control of Shanghai, and to provide references for promoting the digital and intelligent process of disease control and management. Method/Process Using big data and visualization technology, a comprehensive management platform for disease prevention and control is constructed. The application scenarios of data supervision business of the platform are discussed. The data uploading status is statistically analyzed to compare the quality of business data collection before and after the application of the platform. Result/Conclusion The application of the comprehensive management platform for disease prevention and control will provide new path for the development trend analysis of disease control and prevention, data integration and sharing, and operation supervision.