Purpose/Significance To develop a shared service platform, so as to promote the cross-institutional clinical data sharing and application in Henan province. Method/Process The practical problems and demands faced by cross-institutional clinical data sharing in Henan province are analyzed. A platform is constructed around 3 core requirements:data collection, governance and production, and delivery and sharing. Standardized data interaction interfaces are developed, and an integrated platform for data governance and development as well as a shared service platform are established. Result/Conclusion Clinical data from 114 medical institutions in Henan province are integrated into the platform. A multi-center clinical database comprising 2 589 variable fields is built, along with 3 disease-specific datasets for lung cancer, female cancers, and diabetes. These resources provide high-quality real-world data to support healthcare administrators, clinical practitioners, and medical researchers, and provide references for regional clinical data sharing and application initiatives in China.