Purpose/Significance To establish a framework for the biosafety big data standard system, and to provide references for the development of related standards. Method/Process The standard category item pool of the biosafety big data standard system is constructed by the literature review method, the framework of the standard system is initially constructed by the three-dimensional structure method, and the Delphi method is used for optimization and refinement. Result/Conclusion The framework of the biosafety big data standard system is proposed, including 7 first-level standard categories such as basic standards, data standards, and technical standards, as well as 26 second-level standard categories, strengthening the top-level design of biosafety big data standards.