Purpose/Significance Utilizing emerging technologies in the digital intelligence era to fully explore the knowledge of traditional Chinese medicine (TCM) ancient books and bring the content contained in them to life. Method/Process The connotation of the activation of TCM ancient books in the digital intelligence era is expounded. The knowledge reconstruction path and model for the activation of TCM ancient books are discussed. The development strategies to the activation of TCM ancient books are explained from three dimensions:theoretical dimension, technical dimension, and user dimension. Result/Conclusion In the digital intelligence era, the construction of knowledge reconstruction path and model for the activation of TCM ancient books can effectively promote the transformation and application of digital resources of TCM ancient books, fully explore the value of TCM ancient medical books, and thus better inherit and develop the traditional culture of TCM.