Purpose/Significance To construct an ontology of integrated traditional Chinese and western medicine in treatment of diabetic retinopathy (DR), so as to provide a comprehensive and integrated treatment strategic support for related fields. Method/Process Based on the FAIR principle, Protégé 5.6.0 is used to construst the ontology. Result/Conclusion The ontology includes a total of 48 classes, 14 object attributes, 26 data attributes, and 412 instances. It basically realizes the semantic expression of knowledge in the field, which is conducive to the reasoning and sharing of related knowledge and provides support for the construction of knowledge graphs and intelligent application research in related fields.